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Date: 12-7-2016
3317
Date: 3-12-2015
2739
Date: 10-5-2019
1769
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Both ‘Grignard reagents’ and organolithiums are particularly useful in nucleophilic addition reactions with carbonyl electrophiles, such as ketones:
The nucleophilic carbon need not be primary as in the picture above. The synthesis of 2-phenyl-2-propanol, for example, can be carried by reacting phenylmagnesium bromide with acetone.
Addition to formaldehyde gives 1o alcohols