Oligosaccharide Structure

The oligosaccharide (glycan) components of glycoproteins are generally branched heteropolymers composed primarily of D-hexoses, with the addition in some cases of neuraminic acid (a nonose) and of L-fucose, a 6-deoxyhexose.
A. Carbohydrate–protein linkage
The glycan may be attached to the protein through an N- or an O-glycosidic link . In the former case, the sugar chain is attached to the amide group of an asparagine side chain and, in the latter case, to the hydroxyl group of either a serine or threonine side chain. [Note: In the case of collagen, there is an O-glycosidic linkage between galactose or glucose and the hydroxyl group of hydroxylysine .]
B. N- and O-Linked oligosaccharides
A glycoprotein may contain only one type of glycosidic linkage (N or O linked) or may have both types within the same molecule.
1. O-Linked: The O-linked glycans may have one or more of a wide variety of sugars arranged in either a linear or a branched pattern. Many are found in extracellular glycoproteins or as membrane glycoprotein components. For example, O-linked oligosaccharides on the surface of red blood cells help provide the ABO blood group determinants. If the terminal sugar on the glycan is GalNAc, the blood group is A. If it is galactose, the blood group is B. If neither GalNAc nor galactose is present, the blood group is O.
2. N-Linked: The N-linked glycans fall into two broad classes: complex oligosaccharides and high-mannose oligosaccharides. Both contain the same pentasaccharide core shown in Figure 1, but the complex oligosaccharides contain a diverse group of additional sugars, for example, GlcNAc, GalNAc, L-fucose, and NANA, whereas the highmannose oligosaccharides contain primarily mannose.

Figure 1: Complex (top) and high-mannose (bottom) N-linked oligosaccharides. [Note: Members of each class contain the same pentasaccharide core (shown inside the box).] NANA = N-acetylneuraminic acid; Gal = galactose; GlcNAc = N-acetylglucosamine; Man = mannose; Fuc = fucose; Asn = asparagine.

مواضيع ذات صلة

آلية عمل المجموعة الأولى من الهرمونات

الهرمونات وآليات الاستتباب

تدرك (تقويض) الهرمونات وتعطيلها

نقل الهرمونات في البلازما

تغاير خزن الهرمونات وإفرازها

تخليق POMC ومعالجته

The Amino Acids

Absorption & Transport of Transition Metals

Physiologic Roles of The Essential Transition Metals

تخليق الأنجيوتنسين

تخلیق PTH

تخليق الأنسولين