Claisen condensation Reaction mechanism
المؤلف:
University of Missouri System
المصدر:
Organic Chemistry ii
الجزء والصفحة:
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21-10-2020
2558
Claisen condensation
Earlier, we examined the aldol reactions as a nucleophilic carbonyl addition in section 20.6, in which the electrophile is the carbonyl carbon of an aldehyde or ketone. A nucleophilic enolate can also attack the carbonyl carbon of a carboxylic acid derivative in a nucleophilic acyl substitution reaction.
This is referred to as a Claisen condensation, after the German chemist Ludwig Claisen (1851-1930).
Basic reaction
Going from reactants to products simply 
Example: Claisen Condensation
Claisen condensation mechanism
1) Enolate formation
2) Nucleophilic attack
3) Removal of leaving group
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