Substitutes on Neighboring Carbons Slow Nucleophilic Substitution Reactions
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31-7-2019
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Substitutes on Neighboring Carbons Slow Nucleophilic Substitution Reactions
Previously we learned that adding R groups to the electrophilic carbon results in nucleophilic substitution reactions that occur at a slower rate. What if R groups are added to neighboring carbons? It turns out that the addition of substitutes on neighboring carbons will slow nucleophilic substitution reactions as well.
In the example below, 2-methyl-1-bromopropane differs from 1-bromopropane in that it has a methyl group attached to the carbon that neighbors the electrophilic carbon. The addition of this methyl group results in a significant decrease in the rate of a nucleophilic substitution reaction.
If R groups were added to carbons farther away from the electrophilic carbon, we would still see a decrease in the reaction rate. However, branching at carbons farther away from the electrophilic carbon would have a much smaller effect.
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