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Gilman Reagents

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المصدر:  LibreTexts Project

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28-7-2019

1641

Gilman Reagents

Another important reaction exhibited by organometallic reagents is metal exchange. Organolithium reagents react with cuprous iodide to give a lithium dimethylcopper reagent, which is referred to as a Gilman reagent. Gilman reagents are a source of carbanion like nucleophiles similar to Grignard and Organo lithium reagents. However, the reactivity of organocuprate reagents is slightly different and this difference will be exploited in different situations. In the case of α, β unsaturated carbonyls organocuprate reagents allow for an 1,4 addition of an alkyl group. As we will see later Grignard and Organolithium reagents add alkyl groups 1,2 to α, β unsaturated carbonyls

Organocuprate reagents are made from the reaction of organolithium reagents and CuI

This acts as a source of R:^-