Reactions of α-Amino Acids : Carboxylic Acid Esterification

Amino acids undergo most of the chemical reactions characteristic of each function, assuming the pH is adjusted to an appropriate value. Esterification of the carboxylic acid is usually conducted under acidic conditions, as shown in the two equations written below. Under such conditions, amine functions are converted to their ammonium salts and carboxyic acids are not dissociated. The first equation is a typical Fischer esterification involving methanol. The initial product is a stable ammonium salt. The amino ester formed by neutralization of this salt is unstable, due toacylation of the amine by the ester function.
The second reaction illustrates benzylation of the two carboxylic acid functions of aspartic acid, using p-toluenesulfonic acid as an acid catalyst. Once the carboxyl function is esterified, zwitterionic species are no longer possible and the product behaves like any 1º-amine.

مواضيع ذات صلة

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البروتينات proteints

الببتيدات Peptides

الأحماض الامينية غير البروتنيية

تصنيف الأحماض الامينية Classification of amino acids

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الفعالية البصرية للأحماض الامينية Optical activity of amino acids

الأحماض الامينية

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تقدير الوزن الجزيئي للبروتينات