Medicinal chemistry

   Medicinal chemistry is concerned with the chemistry of compounds that have a beneficial effect on a disease. Its objective is to enhance this beneficial therapeutic effect of a compound by modifying its structure and to remove unwanted side effects through an understanding of the chemistry by which the compound exerts its biological effects. Once a lead substance with a useful biological effect has been discovered, the medicinal chemist must undertake a series of structural variations in order to establish a pattern of structure: activity relationships leading to an enhancement of the useful biological effect. While the medicinal chemist is primarily concerned with the synthesis of new therapeutic agents, there must be a considerable interaction with other disciplines; medicine and biology for the description of the disease state and the development of the bio-assay, pharmacology for the definition of the site of action and pharmacy for the delivery of the compound to the living system.

مواضيع ذات صلة

Alzheimer’s Disease

THE TREATMENT OF HYPERTENSION

β1-ADRENERGIC ANTAGONISTS ‘ β-BLOCKERS’

β-ADRENERGIC RECEPTOR AGONISTS – THE DEVELOPMENT OF ANTI-ASTHMA DRUGS

α-ADRENERGIC RECEPTOR AGONISTS

THE ADRENERGIC RECEPTORS

CATECHOLAMINES AS NEUROTRANSMITTERS

LOCAL ANAESTHETICS

MUSCARINIC AGONISTS

NEUROMUSCULAR BLOCKING AGENTS IN SURGERY

ACETYLCHOLINE

AGONISTS AND ANTAGONISTS