Reduction of Other Functional Groups that Contain Nitrogen
المؤلف:
University of Missouri System
المصدر:
Organic Chemistry ii
الجزء والصفحة:
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28-10-2020
1629
Reduction of Other Functional Groups that Contain Nitrogen
Reduction of Nitro Groups
Several methods for reducing nitro groups to amines are known. These include catalytic hydrogenation (H2 + Pd/C), zinc or tin in dilute HCl, and sodium sulfide in ammonium hydroxide solution.
Nitriles can be converted to 1° amines by reaction with LiAlH4
During this reaction the hydride nucleophile attacks the electrophilic carbon in the nitrile to form an imine anion. Once stabilized by a Lewis acid-base complexation the imine salt can accept a second hydride to form a dianion. The dianion can then be converted to an amine by addition of water.
Amides can be converted to 1°, 2° or 3° amines using LiAlH4
الاكثر قراءة في مواضيع عامة في الكيمياء العضوية
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