Conversion of nitriles to amides
المؤلف:
University of Missouri System
المصدر:
Organic Chemistry ii
الجزء والصفحة:
.................
16-10-2020
2372
Conversion of nitriles to amides
Nitriles can be converted to amides. This reaction can be acid or base catalyzed. In the case of acid catalysis the nitrile becomes protonated. Protonation increases the electrophilicity of the nitrile so that it will accept water, a poor nucleophile.
Mechanism
1) Protonation
2) Nucleophilic attack by water
3) Proton Transfer
4) Resonance
5) Deprotonation
الاكثر قراءة في مواضيع عامة في الكيمياء العضوية
اخر الاخبار
اخبار العتبة العباسية المقدسة
