Using Aldol Reactions in Synthesis
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22-11-2019
1662
Using Aldol Reactions in Synthesis
Aldol reactions are excellent methods for the synthesis of many enones or beta hydroxy carbonyls. Because of this, being able to predict when an aldol reaction might be used in a synthesis in an important skill. This accomplished by mentally breaking apart the target molecule and then considering what the starting materials might be.
Fragments which are easily made by an aldol reaction
Steps to 'reverse' the aldol reaction (from the final aldol product towards identifying the starting compounds).
1) From an enone break the double bond and form two single bonds. Place and OH on the bond furthest from the carbonyl and an H on the bond closest to the carbonyl.
2) From the aldol product break the C-C bond between the alpha carbon and the carbon attached to the OH. Then turn the OH into a carbonyl and add an hydrogen to the other carbon.
Example 1
What reactant must be used to make the following molecule using an aldol condensation?
SOLUTION
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