Some limitations of Friedel-Crafts Alkylation
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27-8-2019
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Some limitations of Friedel-Crafts Alkylation
There are possibilities of carbocation rearrangements when you are trying to add a carbon chain greater than two carbons. The rearrangements occur due to hydride shifts and methyl shifts. For example, the product of a Friedel-Crafts Alkylation will show an iso rearrangement when adding a three carbon chain as a substituent. Also, the reaction will only work if the ring you are adding a substituent to is not deactivated. For a look at substituents that activate or deactivate a benzene ring, check out the wiki page: Activating and Deactivating Benzene Rings One way to resolve these problems is through Friedel-Crafts Acylation.
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