Genomic Comparisons Will Have Increasing Importance in Human Biology and Medicine
المؤلف:
David L. Nelson, Michael M. Cox
المصدر:
Lehninger Principles of Biochemistry 6th ed 2012
الجزء والصفحة:
6th ed -p28
26-7-2016
1968
Genomic Comparisons Will Have Increasing Importance in Human Biology and Medicine
The genomes of chimpanzees and humans are 99.9% identical, yet the differences between the two species are vast. The relatively few differences in genetic endowment must explain the possession of language by humans, the extraordinary athleticism of chimpanzees, and myriad other differences. Genomic comparison will allow researchers to identify candidate genes linked to divergences in the developmental programs of humans and the other primates and to the emergence of complex functions such as language. The picture will become clearer only as more primate genomes become available for comparison with the human genome. Similarly, the differences in genetic endowment among humans are vanishingly small compared with the differences between humans and chimpanzees, yet these differences account for the variety among us—including differences in health and in susceptibility to chronic diseases. We have much to learn about the variability in sequence among humans, and during the next decade the availability of genomic information will almost certainly transform medical diagnosis and treatment. We may expect that for some genetic diseases, palliatives will be replaced by cures; and that for disease susceptibilities associated with particular genetic markers, forewarning and perhaps increased preventive measures will prevail. Today’s “medical history” may be replaced by a “medical forecast.”
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