Poliomyelitis

Causative agent poliovirus is the member of the family picornaviridae which is one of the largest and most important families of human pathogens .these are smallest RNA viruses .Despite a member of enterovirus poliovirus as well as other enterovirus don’t produce enteric disease they are named because the alimentary canal is their predominant site of replication

Vaccine against poliomyelitis

There are two kinds of vaccines for immunization against virus

1. a vaccine mad of noninfectious virus particles ( killed or inactivated virus vaccine administered by injection referred to as killed poliovaccine KPV or inactivated poliovaccine IPV )
2. made of infectious virus particles attenuated in neurovirulence (live attenuated virus vaccine LPV  administered orally referred to as live poliovaccine or oral poliovaccine OPV )

Oral polio virus vaccine

the trivalent oral poliovirus vaccine TOPV is mixture of three types (monovalent ) of attenuated polioviruses which are propagated separately in appropriate cell cultures and then mixed .A stabilizer magnesium chloride is added to this blended mixture .Each dose contains less than 25μg of each of the antibiotics ,streptomycin and neomycin .phenol added as indicator of the PH, before  being released by the manufacturer the vaccine in final containers is kept continuously in the frozen temperature below -20 C .under this condition of storage ,the expiry date of vaccine is fixed which is not more than two years. after thawing OPV may be refrigerated at temperature of 2-8 C for a period not exceeding 30 days .

inactivated poliovirus vaccine

this vaccine contains 40,8 and 32 D unit respectively of type 1,2 and 3 in each dose of the vaccine which gives adequate immunity after two doses given parenterally

Advantages with IPV

1. confers humoral immunity in a satisfactory proportion of vaccines if a sufficient number of doses are given .
2. incorporated into regular pediatric immunization with other DPT
3. Absence of living virus precludes potential mutation and reversion to virulence
4. Absence of living virus permits it is use in immunodeficient or immunosuppressed individuals and their households .
5. Reduced the spread of polioviruses in small countries where it has been properly used

Disadvantage of IPV

1. repeated boosters required to maintain detectable ab level
2. doesn’t induce local (intestinal ) immunity in the vaccine
3. more costly than OPV

Advantage with OPV

1. confers humoral both systemic and intestinal immunity like natural infection
2. immunity that induced may be life long
3. oral administered is more acceptable to vaccine than injection and easier to accomplish

Disadvantage with OPV  

1. being live viruses the vaccine viruses do mutate and in rare instance have reverted towards neurovirulence significantly to cause paralytic inreciepients or their contacts
2. vaccine progeny virus spread to household contact
3. contraindication in those with immunedeficiency disorder and their household contact as well as individuals under going immunossupression therapy

Differences between OPV and IPV

Efficacy of poliovirus vaccine

The presence of humoral antibodies has been seen after 7-15 years of immunization with IPV

IPV has also been shown to induce good protection in persons in tropical countries where OPV may fail to uniformly immunize because of the presence of the inhibitors of the vaccine virus in the gastrointestinal tract especially in developing tropical countries .

OPV : the persistence of humoral ab after vaccinating with OPV has been reported up to 15 years or even more . Seroconversion in virtually  100% recipients .There are several problems with OPV such as occurrence of vaccine associated paralytic poliomyelitis cases in developed countries and failure of OPV  to cause seroconversion .

OPV is unstable unless kept at very low temperature .Current recommendations indicate that after thawing ,OPV be held at no more than 10 C for less than 30 days .At 0-8 C the virus can be stored for 6-12 months without a loss in titre.

Immunization schedules

OPV : the centres for disease control (CDC) recommends that primary immunization with OPV should commence at the age of two months ,the second and third doses should be given at 2 months interval there after ,and fourth dose should be given at 18 months of age .

If the child vomits within one hour of receiving the oral poliovaccine a further dose may be given the next day .

Contraindication to OPV

1-Acute febrile illness b- sever diarrhea and vomiting  c- Sensitivity to antimicrobial agents in vaccine preparation

d- Immunodeficiency and malignancy e- pregnancy f- If there has been a serious reaction t  o a previous vaccination with OPV eg .anaphylactic reaction

Adverse reactions

Vaccine associated paralysis in recipients is very rare about one in 2 million doses administration

IPV : The CDC recommends first dose of IPV at 6-12 weeks of age followed by two doses after intervals of 4-8 weeks .The fourth dose is recommended after 6-12 months of the third dose and supplementary booster at the age of 4-6 years ,Subsequent boosters may be administered every five years till the age of 18 years .

مواضيع ذات صلة

Adjuvants

New Approaches to Vaccine Development​

The Need for New Vaccines

Toxoid Vaccines

Recombinant Protein Vaccines

Capsular Polysaccharide Vaccines and Protein Carriers (Conjugate Vaccines)

Subunit Vaccines

Inactivated Vaccines

Live, Attenuated Vaccines

Types of Vaccines in Current Use

Vaccinia Virus

اللقاحات الوقائية Vaccines