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Methods of analysis , Confirming meconium for drugs of abuse

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  260

2026-10-21

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Methods of analysis

Confirming meconium for drugs of abuse

 There are several published confirmation methods, primarily GC-MS but also HPLC or LC MS, for the determination of drugs of abuse and their metabolites in meconium. Reported analytes include cocaine, norcocaine, benzoyl norecgonine, cocaethylene, ecgonine methyl ester, m-hydroxy benzoylecgonine, and more recently, p-hydroxy benzoylecgonine, anhydro ecgonine methyl ester and ecgonine ethyl ester, morphine, hydrocodone, hydromorphone, methadone and its principal metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrroli dine (EDDP), as well as codeine, metham fetamine and amfetamine, marijuana (11-nor-D9-tetrahydrocannabinol-9-carboxylic acid), phencyclidine, and nicotine and metabolites (cotinine and trans-3-hydroxycotinine). The solid phase extraction or solvent extraction of drugs from meconium is typically followed by instrumental analysis with or without derivatization.