تسجيل الدخول

تسجيل

oxicological screening , Cholinesterase inhibitors (organophosphate and carbamate pesticides)

المؤلف:  Sue Jickells , Adam Negrusz (Editors)

المصدر:  Clarkes Analytical Forensic Toxicology

الجزء والصفحة:  p231-232

2026-10-17

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oxicological screening

Cholinesterase inhibitors (organophosphate and carbamate pesticides)

There are no simple direct chemical tests for these compounds. The toxic effects are usually associated with depression of the cholinesterase activity of the body, and measurement of the plasma or serum cholinesterase can be used as an indication of organophosphorus or carbamate poisoning. Plasma or serum cholinesterase (pseudocholinesterase) is inhibited by a number of compounds and can also be decreased in the presence of liver impairment. Erythrocyte cholinesterase (true cholinesterase) reflects more accurately the cholinesterase status of the central nervous system. However, pseudo cholinesterase activity responds more quickly to an inhibitor and returns to normal more rapidly than erythrocyte-cholinesterase activity. Thus, measurement of pseudocholinesterase activity is quite adequate for diagnosing acute expo sure to organophosphorus or thiocarbamate compounds, but cases of illness that may be caused by chronic exposure to these compounds should also be investigated by determining the erythrocyte-cholinesterase activity.