Polysaccharides:- Glycoproteins Have Covalently Attached Oligosaccharides

Glycoproteins are carbohydrate-protein conjugates in which the carbohydrate moieties are smaller and more structurally diverse than the glycosaminoglycans of proteoglycans. The carbohydrate is attached at its anomeric carbon through a glycosidic link to the -OH of a Ser or Thr residue (O-linked), or through an N-glycosyl link to the amide nitrogen of an Asn residue (N-linked) (Fig. 7–31). Some glycoproteins have a single oligosaccharide chain, but many have more than one; the carbohydrate may constitute from 1% to 70% or more of the glycoprotein by mass. The structures of a large number of O- and N-linked oligosaccharides from a variety of glycoproteins are known; Figure 7–31 shows a few typical examples. As we shall see in Chapter 11, the external surface of the plasma membrane has many membrane glycoproteins with arrays of covalently attached oligosaccharides of varying complexity. One of the best-characterized membrane glycoproteins is glycophorin A of the erythrocyte membrane (see Fig. 11–8). It contains 60% carbohydrate by mass, in the form of 16 oligosaccharide chains (totaling 60 to 70 monosaccharide residues) covalently attached to amino acid residues near the amino terminus of the polypeptide chain. Fifteen of the oligosaccharide chains are O-linked to Ser or Thr residues, and one is N-linked to an Asn residue. Many of the proteins secreted by eukaryotic cells are glycoproteins, including most of the proteins of blood. For example, immunoglobulins (antibodies) and certain hormones, such as follicle-stimulating hormone, luteinizing hormone, and thyroid-stimulating hormone, are glycoproteins. Many milk proteins, including lactalbumin, and some of the proteins secreted by the pancreas (such as ribonuclease) are glycosylated, as are most of the proteins contained in lysosomes.

FIGURE 7–29 Proteoglycan aggregate of the extracellular matrix. One very long molecule of hyaluronate is associated noncovalently with about 100 molecules of the core protein aggrecan. Each aggrecan molecule contains many covalently bound chondroitin sulfate and keratan sulfate chains. Link proteins situated at the junction between each core protein and the hyaluronate backbone mediate the core protein–hyaluronate interaction.

A number of cases are known in which the same protein produced in two types of tissues has different glycosylation patterns. For example, the human protein interferon IFN-

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مواضيع ذات صلة

Nucleic Acid Structure:- DNA Stores Genetic Information

Carbohydrates as Informational Molecules: The Sugar Code:- Lectin-Carbohydrate Interactions Are Very Strong and Highly Specific

Carbohydrates as Informational Molecules: The Sugar Code:- Lectins Are Proteins That Read the Sugar Code and Mediate Many Biological Processes

Polysaccharides:- Glycolipids and Lipopolysaccharides Are Membrane Components

Polysaccharides:- Proteoglycans Are Glycosaminoglycan-Containing Macromolecules of the Cell Surface and Extracellular Matrix

Polysaccharides:- Glycosaminoglycans Are Heteropolysaccharides of the Extracellular Matrix

Polysaccharides:- Bacterial and Algal Cell Walls Contain Structural Hetero polysaccharides

Polysaccharides: -Steric Factors and Hydrogen Bonding Influence Homopolysaccharide Folding

Polysaccharides:- Some Homopolysaccharides Serve Structural Roles

Polysaccharides:- Some Homopolysaccharides Are Stored Forms of Fuel

Monosaccharides and Disaccharides:- Disaccharides Contain a Glycosidic Bond

Monosaccharides and Disaccharides:- Monosaccharides Are Reducing Agents