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تسجيل

5′-nucleotidase

المؤلف:  Kathleen Deska Pagana, Timothy J. Pagana, Theresa Noel Pagana.

المصدر:  Mosbys diagnostic and laboratory test reference

الجزء والصفحة:  15th edition , p652

2026-01-04

667

 Type of test Blood

Normal findings

0-1.6 units at 37° C or 0-1.6 units at 37° C (SI units)

Test explanation and related physiology

5′-Nucleotidase is an enzyme specific to the liver. The 5′-nucleotidase level is elevated in patients with liver diseases, especially those associated with cholestasis. It provides information similar to alkaline phosphatase (ALP). However, ALP is not specific to the liver. When doubt as to the cause of an elevated ALP exists, 5′-nucleotidase is recommended. If that enzyme is elevated along with the ALP, the source of the pathology is certainly in the liver. If the 5′-nucleotidase is normal in the face of an elevated ALP, the source of pathology is outside the liver. Gamma-glutamyl transpeptidase (GGTP). is used similarly because it is also specific to the liver.

Interfering factors

* Drugs that may cause increased 5′-nucleotidase levels include hepatotoxic agents.

Procedure and patient care

• See inside front cover for Routine Blood Testing.

• Fasting: no

• Blood tube commonly used: red

Abnormal findings

Increased levels

- Bile duct obstruction

- Cholestasis

- Hepatitis

- Cirrhosis

- Hepatic necrosis, ischemia, tumor

- Hepatotoxic drugs