Pneumonia is a common complication among patients requiring mechanical ventilation. Prevalence estimates vary between 6 and 52 cases per 100 patients, depending on the population studied. On any given day in the ICU, an average of 10% of patients will have pneumonia— VAP in the overwhelming majority of cases. Although in recent years the frequency of this infection was declining as a result of effective prevention strategies, with the advent of COVID-19, there has been an increase in its frequency. The frequency of VAP changes with the duration of mechanical ventilation, with the highest hazard ratio in the first 5 days and a plateau in additional cases (1% per day) after ~2 weeks. However, the cumulative rate among patients who remain ventilated for as long as 30 days is as high as 70%. These rates often do not reflect the recurrence of VAP in the same patient. Once a ventilated patient is transferred to a chronic-care facility or to home, the incidence of pneumonia drops significantly, especially in the absence of other risk factors for pneumonia. However, in chronic ventilator units, purulent tracheobronchitis becomes a significant issue, often interfering with efforts to wean patients off mechanical ventilation.

Three factors are critical in the pathogenesis of VAP: colonization of the oropharynx with pathogenic microorganisms, aspiration of these organisms from the oropharynx into the lower respiratory tract, and compromise of normal host defense mechanisms. Most risk factors and their corresponding prevention strategies pertain to one of these three factors (Table 1).

Table1. Pathogenic Mechanisms and Corresponding Prevention Strategies for Ventilator-Associated Pneumonia

The most important risk factor is the endotracheal tube, which bypasses the normal mechanical factors preventing aspiration. While the presence of an endotracheal tube may prevent large-volume aspiration, microaspiration is actually exacerbated by secretions pooling above the cuff. The endotracheal tube and the concomitant need for suctioning can damage the tracheal mucosa, thereby facilitating tracheal colonization. In addition, pathogenic bacteria can form a glycocalyx biofilm on the tube’s surface that protects them from both antibiotics and host defenses. The bacteria can also be dislodged during suctioning (done preferably with a closed catheter system) and can reinoculate the trachea, or tiny fragments of a glycocalyx can embolize to distal airways, carrying bacteria with them. The ventilator circuit tubing can harbor pathogenic organisms that can wash back to the patient if manipulated too often; thus, circuits are changed only when soiled and with each new patient. Heat moisture exchangers are changed every 5–7 days or if visibly soiled or malfunctioning.

In a high percentage of critically ill patients, the normal oropharyngeal flora is replaced by pathogenic microorganisms. The most important risk factors are antibiotic selection pressure, cross-infection from other infected/colonized patients or contaminated equipment, severe systemic illness, and malnutrition. Of these factors, antibiotic exposure poses the greatest risk by far. Pathogens such as P. aeruginosa almost never cause infection in patients without prior exposure to antibiotics. The recent emphasis on hand hygiene has lowered the cross-infection rate.

Almost all intubated patients experience microaspiration and are at least transiently colonized with pathogenic bacteria. However, only around one-third of colonized patients develop VAP. Colony counts increase to high levels, sometimes days before the development of clinical pneumonia; these increases suggest that the final step in VAP development, independent of aspiration and oropharyngeal colonization, is the overwhelming of host defenses by a large bacterial inoculum. Severely ill patients with sepsis and trauma appear to enter a state of immunoparalysis several days after admission to the ICU—a time that corresponds to the greatest risk of developing VAP. The mechanism of this immunosuppression is not clear, although hyperglycemia and frequent transfusions adversely affect the immune response.

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العتبة العباسية المقدسة تختتم فعاليات الموكب الثقافي العام ضمن مجموعة مواكب أمّ البنين (عليها السلام)

الأمين العام للعتبة العباسية المقدسة يتابع ميدانيًّا خدمات المواكب والأقسام المقدمة لزائري الأربعين

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مجمع أبي الفضل العباس (عليه السلام) يختتم أعماله الخاصة بزيارة الأربعين بإقامة مجلس عزاء

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مواضيع ذات صلة

Pathology and Microbiology of Lung Abscess

Epidemiology of Community-Acquired Pneumonia

Etiology of Community-Acquired Pneumonia

Causes of Macrocytosis with Normoblastic Erythropoiesis

Urinary tract infection

Genitourinary malformations

Diabetic Foot Ulcers

Kidney transplantation

C3 glomerulopathy

Membranous glomerulonephritis

Focal segmental glomerulosclerosis

Diabetic nephropathy