Proteins as Drug Targets

The majority of drug targets are proteins that are encoded by genes expressed within tissues affected by a disease. It is estimated that there are approximately 10 000 different enzymes, more than 2000 different G-protein-coupled receptors, 200 different ion channels and 100 different nuclear hormone receptors encoded in the human genome. These proteins are key components of the pathways involved in disease and, therefore, are likely to be a rich source of new drug targets.
Proven drug targets share certain other characteristics, which can only be identified by understanding their expression levels in cells and cannot be determined by their gene sequences alone. Drug targets are (1) often expressed primarily in specific tissues, allowing for selectivity of pharmacological action and reducing the potential for adverse side-effects and (2) generally expressed at low abundance in the cells of the relevant organ. An effective target discovery system would therefore allow the detection of genes that encode for proteins expressed in specific tissues at low abundance, thereby permitting the rapid identification of proteins, which are likely to be targets for therapeutic and diagnostic development.

مواضيع ذات صلة

The Biology of Restriction Enzymes

The Isolation of DNA

MODERN BIOTECHNOLOGY

ANCIENT BIOTECHNOLOGY

DEFINITIONS OF BIOTECHNOLOGY

Future Perspectives of Biofuels and Biotechnology

Biobutanol

Ethanol Production from Biomass

Improved Production of Corn Ethanol

Application of Biotechnology Tools to Biofuels Processes

Biodiesel

Production of The Major Biofuels